Longevity Decoded | Executive Peak Performance

We believe aging is not a passive decline

but a dynamic process you can influence.

Learn more about our Executive Peak Performance Program

and how it could empower you and your employees

Watch Dr. Logan’s Full Longevity Decoded Talk Here

Causes of Aging

Inflammation | The silent spark behind many chronic diseases.

Periodontal disease (gum disease) is more than a dental issue, it’s been linked to heart disease due to the spread of inflammatory bacteria through the bloodstream.
Metabolic dysfunction, like insulin resistance (pre-diabetes/diabetes), leads to chronic low-grade inflammation that damages blood vessels and organs over time.
“Inflammaging” is a term for the persistent, low-level inflammation that accelerates aging. Key blood markers include hs-CRP, IL-6, homocysteine, and DNA methylation age, which reflect how your body is aging at the cellular level.
Dietary triggers like excess omega-6 intake from seed oils and processed foods. Many patients we treat show an imbalanced omega-6 to omega-3 ratio, often 10:1 or higher, when the ideal range is closer to 3:1 or 1:1. This skewed ratio can promote systemic inflammation and disrupt cellular signaling.

Mitochondrial Dysfunction | When your cellular power plants start to fail.

Mitochondria produce energy for every cell. Damage from poor diet, toxins, or aging can reduce their efficiency, leading to fatigue and disease.

Some animal studies suggest that certain fats (like those in processed seed oils) may impair mitochondrial function, though human data is mixed.

Hormonal Decline | The body’s internal messengers fade with age.

Hormones like testosterone, DHEA, Progesterone, Estradiol, thyroid hormones, Human Growth Hormone (IGF-1), and cortisol regulate energy, muscle mass, mood, and metabolism.
Testing and optimizing these levels may help maintain vitality and slow age-related decline.

Ideal Baseline Assessment for Comprehensive Diagnostics

Standard labs: Fasting glucose, metabolic panel, CBC, standard lipid panel, liver/kidney function, vitamin D, thyroid, blood hormone testing etc.
Advanced Diagnostic Testing includes: HbA1c, insulin resistance score, continuous blood glucose monitoring, lipid panel with NMR, hs-CRP, oxLDL and other inflammatory markers, liver fibrosis panel (screen for fatty liver), kidney profile/cystatin C, saliva/urine hormone testing (Precision Diagnostics), micronutrient levels (Vibrant Health Laboratory), gut microbiome test, oral DNA, CBCT (cone beam CT scan) of the mouth to evaluate for chronic low grade infection in previous extraction sites including wisdom teeth and root canal treated to determine if there is an underlying source for chronic inflammation
Blood pressure (including home monitoring)
Body composition: weight, BMI, waist circumference, lean muscle mass
Functional tests: hand‐grip strength, gait speed (e.g., 4-meter walk), balance check, v02 max
Review lifestyle: diet, physical activity level, sleep quality, stress levels, social engagement, smoking/alcohol history

Longevity & Healthspan

Can We Influence Healthspan?

Yes, your daily habits and biomarkers can predict and improve how long you stay healthy.

Is Biohacking a Proven Strategy?

It’s not science fiction, it’s self-monitoring with purpose.

Intermittent fasting activates cellular repair, reduces inflammation, and improves metabolism by switching the body from sugar-burning to fat-burning.
Sleep tracking with devices like Whoop or Oura Ring helps optimize recovery, detect stress, and improve heart rate variability (HRV), a key marker of resilience.

Continuous glucose monitors (CGMs) reveal how your body responds to food, helping prevent insulin resistance and metabolic disease.

Functional fitness, grip strength, gait speed, and balance, are powerful predictors of longevity and independence.
Stress management is critical. Chronic stress raises cortisol, which spikes blood sugar and accelerates aging.

Biohacking at Home

Technology can empower your wellness journey, helping you reduce inflammation, improve recovery, and optimize performance from the comfort of your home. Out patients leverage these science-backed products to continue their treatment at home.

Products The Logan Institute uses for at home or in office treatments:

Red:Vive Red Light Therapy: Uses therapeutic wavelengths to support cellular repair, reduce inflammation, and improve skin health.
High Tech Health Infrared Saunas: Promote deep detoxification, cardiovascular support, and relaxation through medical-grade infrared heat.
Power Plate Vibration Therapy: Boosts circulation, accelerates recovery, and enhances mobility with whole-body vibration, trusted by Dr. Logan.
Austin Air Purifiers: Remove airborne toxins, allergens, and mold with HEPA and activated carbon filtration, ideal for respiratory and immune health.

Peptides & Regeneration

Peptide Decline with Age

Peptides are short proteins that signal healing, metabolism, and brain function, but they decline over time.

Dr. Vladimir Khavinson, a Russian gerontologist, has published over 700 studies on peptide bioregulators that may support organ repair, immune function, and cognitive health.

Common Peptides

BPC157: Facilitates repair of damaged tissues including arterial walls, intestinal mucosa and a variety of other tissues
KPV: Shown to reduce intestinal inflammation caused by a variety of conditions
DiHexa: This has positive effects on the production of brain derived neurotrophic factor (BDNF) to support cognitive function and possible brain cell regeneration

Regenerative Therapies

PRF & PRP | Your blood, reimagined as a healing tool.

Platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) are derived from your own blood and rich in growth factors.
- Once separated from the patient's blood PRF or PRP are injected near the site of injury providing the body with a concentrated form of the same growth factors it uses to heal on its own. They stimulate tissue repair, reduce inflammation, and are used in orthopedics, dentistry, and aesthetics.
  - Uses in Aesthetics
    In aesthetic medicine, PRF is a powerful tool for skin rejuvenation and scar repair. We often combine it with microneedling to enhance collagen production and accelerate healing in aging skin, acne scars, and surgical scars. The microchannels created by microneedling allow PRF to penetrate deeply, amplifying its regenerative effects. In some cases, we even create a PRF-based face mask, infusing the skin with growth factors in a gentle, topical format. The result is improved texture, tone, and elasticity, with minimal downtime and natural-looking outcomes.
    - Learn More | Watch Testimonials
  - Uses in Orthopedics
    In orthopedic care, PRF is used to treat a wide range of soft tissue injuries, both chronic and acute. Whether it’s tendonitis, ligament sprains, or joint inflammation, PRF delivers concentrated healing signals directly to the site of injury. We’ve seen remarkable success helping patients recover from conditions like tennis elbow, plantar fasciitis, and rotator cuff irritation. By enhancing the body’s own repair mechanisms, PRF helps restore mobility, reduce pain, and get people back to the activities they love, without relying on steroids or surgery.
    - Learn More | Watch Testimonials
Dr. Rick Miron has pioneered PRF protocols that enhance stem cell recruitment and healing.

PRF is discussed at 1:38

Stem Cell Therapy | Rebuilding from within.

Adipose-derived stem cells (from your own fat) are being studied for joint repair, nerve regeneration, and even cognitive support.
- These cells can become bone, cartilage, or nerve tissue, offering hope for conditions like osteoarthritis and neurodegeneration.
Stem Cell Banking: Collecting and storing one’s own stem cells while you're healthy preserves their regenerative potential for future use. These cells may be used in personalized therapies as regenerative medicine evolves, especially for orthopedic, immune, and neurological conditions. Banked stem cells can also be used by immediate family members!
- Learn More about Stem Cell Banking Here
Donor-Derived Stem Cells: Stem cells from placental or umbilical cord tissue are also being explored for their regenerative properties. While promising, they may carry different immune or ethical considerations compared to autologous (self-derived) cells. At The Logan Institute we do not advocate for the use of donor derived stem cells.

Supplementation To Support Longevity

How to Supplement Correctly | Targeted, consistent, and science-backed.

Supplements work best when they’re personalized to your body’s needs. Start by getting tested for nutrient deficiencies, common labs can assess levels of vitamin D, B12, magnesium, omega-3s, and more. Once you know what’s missing, choose high-quality supplements with efficacious doses, meaning the amount matches what research shows to be effective. Take them consistently, ideally at the same time each day, and monitor how you feel. Re-test every 3-6 months to track progress and adjust as needed. Supplementing isn’t a one-time fix, it’s a cycle of testing, dosing, and refining to support long-term health.

Supplement Safety & Quality | Navigating the supplement industry with confidence.

While supplements can support longevity, the industry is largely unregulated, meaning not all products are created equal. Some brands may use low-quality ingredients, ineffective doses, or misleading labels. To protect your health and investment:

Buy directly from the manufacturer or from trusted retail pharmacies with transparent sourcing and third-party testing.
Avoid generic online marketplaces where counterfeit or expired products may circulate.
Check for efficacious doses, meaning the amount of each ingredient matches what research shows to be effective.
Look for certifications like NSF, USP, or GMP, which indicate quality control and purity.
Be skeptical of “proprietary blends” that hide ingredient amounts behind vague formulas.
Consult your physician or pharmacist before starting new supplements, especially if you take medications or have chronic conditions.

Supplements can be powerful tools, but only when chosen wisely and integrated into a broader health strategy.

View Our Supplement Safety Guide

Nutrients That Matter for Long Term Wellbeing

NAD+ precursors (like NMN) support cellular energy and DNA repair.
Urolithin A boosts mitochondrial health and muscle endurance.
Omega-3 fatty acids reduce inflammation and support brain and heart health.
Vitamin D strengthens bones and immunity.
Folate, B12, and B-complex support brain health and methylation.
Magnesium threonate/glycinate aids sleep, cognition, and muscle function.
Spore-based probiotics improve gut health, which influences immunity, mood, and metabolism

Learn More Here: 7 Research-Backed Supplements for Long-Term Vitality

Intervention Targets for Patients

Physical activity: Aim for at least 150 minutes/week of moderate aerobic activity + 2-3 sessions/week of resistance training (strength) + balance/flexibility. Given your age, muscle strength is especially important.
Diet: Adopt or maintain a diet emphasizing vegetables/fruits, whole grains, lean protein, fish (especially oily fish for omega-3), moderate alcohol (if you drink), minimal processed foods/refined carbs. Consider a Mediterranean-type diet.
Body composition / weight: If overweight or high waist circumference, aim for gradual reduction to healthy range; if lean, focus on preserving lean mass, avoiding sarcopenia.
Metabolic markers: Keep fasting glucose, insulin, HbA1c, lipids, BP, inflammation in optimal ranges. If abnormal, work with your doctor for lifestyle + possible medications.
Muscle/frailty prevention: Focus on maintaining muscle mass, strength, and functional mobility (grip strength, gait speed, balance).
Omega-3 + vitamin D + exercise synergy: Consider fish oil/omega-3 supplementation (after consulting your provider), ensuring adequate vitamin D, and exercise for combined benefit.
Sleep & stress: Ensure you get good‐quality sleep (7-9 hrs ideally), manage stress (meditation, mindfulness, social connection), ensure social engagement, mental/cognitive stimulation.
Regular follow‐up & re-assessment: Monitor your biomarkers annually (or more often if needed), reassess functional measures; if you used advanced biomarkers, track changes over time in conjunction with your lifestyle changes.
Regenerative Therapy: Other considerations would include peptide therapy, stem cell therapy, regenerative therapy (PRF/PRP) on a case by case basis

The Logan Institute's Executive Peak Performance Program

Ready to Elevate Your Executive Team?

Every Executive Peak Performance program is individually structured to align with the unique goals and culture of the company we partner with. There is no one‑size‑fits‑all approach, each engagement is designed to meet your team’s specific objectives. It all begins with an introductory call, where we learn about your leadership team, explore your teams health priorities, and determine whether we’re the right fit to help you achieve lasting results.

We’re currently onboarding a limited number of corporate partners for our next cohort. If you’d like to learn more about how the Executive Peak Performance Program can transform your leadership team, share your email with us and we’ll keep you informed as new openings become available.

Interested in bringing the Executive Peak Performance Program to your team?

Learn More

Bibliography

# Claim / Fact	Citation
Periodontal (gum) disease is linked to heart (cardiovascular) disease, likely because oral bacteria enter the bloodstream and trigger inflammation[1].	Corredor, Z., Suarez-Molina, A., Fong, C., Cifuentes-C, L., et al. (2022). Presence of periodontal pathogenic bacteria in blood of patients with coronary artery disease. Scientific Reports, 12, 1241.
Insulin resistance causes chronic low-grade inflammation that damages blood vessels and organs[2].	Natali, A., Toschi, E., Baldeweg, S., Ciociaro, D., Favilla, S., Saccà, L., & Ferrannini, E. (2006). Clustering of insulin resistance with vascular dysfunction and low-grade inflammation in type 2 diabetes. Diabetes, 55, 113–120.
Chronic low-level inflammation (“inflammaging”) increases with age and contributes to age-related diseases[3].	Meier, H. C. S., Mitchell, C., Karadimas, T., & Faul, J. D. (2023). Systemic inflammation and biological aging in the Health and Retirement Study. GeroScience, 45, 3257–3265.
Blood markers of inflammation (e.g. high-sensitivity CRP and IL-6) rise with “inflammaging”[3].	Meier et al. (2023). GeroScience.
Higher systemic inflammation is associated with accelerated “DNA methylation age” (an epigenetic aging biomarker)[4].	Meier et al. (2023). GeroScience.
A very high dietary omega‑6:omega‑3 ratio (≈10:1 vs an often-suggested ideal ~3:1) is claimed to promote chronic inflammation[5].	DiNicolantonio, J. J., & OKeefe, J. H. (2021). Importance of low omega‑6/omega‑3 ratio in future therapeutics. Missouri Medicine, 118(2), 129–134.
Mitochondria produce most of each cell’s ATP (energy), and damage to mitochondria (from aging, toxins, etc.) lowers cellular energy and can cause fatigue and disease[6][7].	National Institute on Aging. (2023). Mitochondria and health. (NIH website)[6][7]
Studies (mainly in animals) suggest fats high in omega‑6 (like processed seed oils) can impair mitochondrial function[8], but human data are limited or mixed.	DiNicolantonio, J. J., Barroso, J., & O’Keefe, J. H. (2023). Linoleic acid: metabolic and health aspects. Missouri Medicine, 120, 177–186.
Hormones such as testosterone, thyroid hormones, IGF‑1 (growth hormone), DHEA, estrogen/progesterone, and cortisol regulate metabolism, energy, muscle mass, mood, etc. For example, testosterone is anabolic for muscle (promotes protein synthesis) and declines with age[9]; cortisol mediates the stress response and raises blood sugar (regulates metabolism)[10].	Nassar, G. N., & Leslie, S. W. (2023). Physiology, Testosterone. In StatPearls [Internet]; Thau, L., Gandhi, J., & Sharma, S. (2023). Physiology, Cortisol. In StatPearls [Internet].
Optimizing or replacing these hormones to slow aging has mixed evidence. In fact, hormone-replacement therapies often produce adverse effects outweighing benefits[11], so hormone optimization to extend lifespan is not proven.	Pataky, M. W., Young, W. F., & Nair, K. S. (2021). Hormonal and metabolic changes of aging... Mayo Clinic Proceedings, 96(3), 788–814. (See discussion of HRT)[11]
Intermittent fasting (e.g. time-restricted eating) has been shown to activate cellular repair (autophagy), reduce inflammation, and shift metabolism from using glucose to burning fat[12].	Longo, V. D., & Panda, S. (2016). Fasting, circadian rhythms, and time‑restricted feeding in healthy lifespan. Cell Metabolism, 23(6), 1048–1059. (Review)[12]
Monitoring sleep and heart-rate variability (HRV) can help detect stress and recovery status; notably, people with higher HRV tend to have better cardiovascular fitness and stress resilience[13].	Harvard Health Publishing. (2024). Heart Rate Variability. (Harvard Health Blog)[13]
Physical function tests predict longevity: for example, stronger grip strength is strongly linked to lower mortality risk[15]. Similarly, faster gait speed and better balance are known to predict longer, independent life in older adults (supported by many studies).	Garcia-Hermoso, A., et al. (2018). Muscular strength as predictor of mortality: a meta-analysis. Archives of Physical Medicine and Rehabilitation, 99(9), 1893–1903.[15]
Chronic stress elevates cortisol chronically, which spikes blood sugar and promotes inflammation; sustained stress has been linked to accelerated aging (e.g. via telomere shortening). Cortisol “mediates the stress response and regulates metabolism”[10].	Thau et al. (2023). Physiology, Cortisol. StatPearls [Internet][10]
BPC‑157 (a peptide from gastric juices) has shown tissue‑healing and angiogenic effects in many animal studies[16], but human clinical data are minimal, so its clinical efficacy is not established.	Szijártó, A., et al. (2022). Regeneration or Risk? A review of BPC-157 in tissues. International Journal of Molecular Sciences, 23(2), 1241.[16]
The peptide KPV (a fragment of alpha-MSH) has been shown to reduce intestinal inflammation in mouse models of colitis[17]. This is animal evidence; human clinical data are minimal, so its clinical efficacy is not established.	Dalmasso, G., et al. (2007). KPV peptide reduces colitis in mice. Journal of Clinical Investigation, 117(8), 212–219. [Animal study][17]
The peptide Dihexa (an angiotensin IV analog) has demonstrated potent neurotrophic effects in animal studies – activating HGF/c-Met signaling and improving cognition in rodent models[18]. Human clinical data is minimal, so its clinical efficacy is not established.	Alzheimer's Drug Discovery Foundation. (2021). Dihexa enhances HGF signaling for brain repair. [White paper][18]
PRP/PRF (platelet-rich plasma/fibrin) are preparations from a patient’s own blood that concentrate platelets; platelets contain numerous growth factors that stimulate healing[19].	Johns Hopkins Medicine. (2024). Platelet-rich plasma (PRP) injections. (Patient info sheet)[19]
Injected PRP/PRF delivers concentrated growth factors to injury sites, which can accelerate tissue repair, reduce inflammation and pain[20]. These are widely used in orthopedics, dentistry, and cosmetic/aesthetic treatments to support healing.	Johns Hopkins Medicine. (2024). Platelet-rich plasma (PRP) injections.[20]
Autologous (self-derived) adipose stem cells (from fat) are being researched for regenerative use. Clinical studies in osteoarthritis show improved pain and cartilage thickness[21], and reviews suggest ADSCs secrete factors that aid nerve regeneration[22].	Sajadi, S., et al. (2025). Adipose-derived MSCs in knee osteoarthritis: triple-blind trial results. Stem Cell Research & Therapy, 16, 242.[21]; Mohan, S. P., et al. (2025). ADSCs for peripheral nerve regeneration. Neurology International, 17(2), 23.[22]
Adipose MSCs can differentiate into cartilage (chondrocytes), bone and even neural cells; this underlies their potential in osteoarthritis and neurodegenerative therapy[21][22].	Sajadi et al. (2025) Stem Cell Res Therapy; Mohan et al. (2025) Neurology Int.
Stem cells from donors (placenta/umbilical cord) are under investigation for regenerative therapies. They have shown promise but carry immune compatibility and ethical issues; they are not yet standard care[21][22].	Sajadi et al. (2025); Mohan et al. (2025). (Same refs as above.)
Dietary supplements are not FDA-approved for efficacy or safety before marketing. Many studies have found that products often contain undeclared or banned substances[23]. Consumers should choose third-party–tested brands.	Richardson, E., Akkas, F., & Cadwallader, A. B. (2022). What should dietary supplement oversight look like in the US? AMA Journal of Ethics, 24(5), E402–E409.[23]

More on Dr. Vladimir Khavinson’s work:

https://dnlabresearch.com/dr-khavinson-pioneering-peptide-therapies/